Srinivasan Vedantham, PhD, DABR, FAAPM

Professor, Radiology and Imaging Sciences and Biomedical Engineering
Director of Biomedical Imaging Innovation / Clinical Translation in Next-Gen CT
Director of the Office for Project Statistical and Design Support

Srinivasan Vedantham, PhD, DABR, FAAPM, is a Professor in the Departments of Radiology and Imaging Sciences and Biomedical Engineering.  He joined the University of Arizona after serving as a faculty at the Department of Radiology at the University of Massachusetts Medical School and as an adjunct faculty in Biomedical Engineering at Worcester Polytechnic Institute.  He received his PhD in Biomedical Engineering from Worcester Polytechnic Institute, Worcester, MA, and subsequently joined as a faculty at the Department of Radiology at Emory University School of Medicine, Atlanta, GA.

Dr. Vedantham has received numerous honors and awards.  He received the Cancer Research Award from the Georgia Cancer Coalition and the Dr. Karen Mudry Award from the Institute of Biomedical Engineering Research (IBER).  He contributed to the article that received the Farrington Daniels Award for the best paper in radiation dosimetry in Medical Physics Journal and the article that was selected as Editor’s Choice in Basic Science in the Journal of Neurointerventional Surgery. 

Dr. Vedantham is a member of several professional organizations: The American Association of Physicists in Medicine (AAPM), the Institute of Electrical and Electronics Engineers (IEEE), and the International Society for Optics and Photonics (SPIE).  He was elected as Fellow by the American Association of Physicists in Medicine (AAPM).   

In addition to his myNCBI site and his University of Arizona profile, additional work by Dr. Vedantham may be also be found on his Google Scholar site.

 

Research Interests: 

Dr. Vedantham’s research interests are in the design, development and clinical translation of novel x-ray imaging systems and imaging techniques with particular focus on oncological and interventional imaging.  He along with his collaborators and colleagues had made major contributions to breast cancer imaging including small-field digital mammography for stereotactic core-biopsies, full-field digital mammography and digital breast tomosynthesis.  Currently, he is working on developing advanced tomographic techniques and systems for breast imaging and its clinical translation.  This design, development and clinical translation oriented research is funded by the National Institutes of Health.  He is also conducting research in interventional imaging with a focus on the development of advanced detector technology.  

Degrees
  • PhD: Worcester Polytechnic Institute, 2002
  • MS: The University of Akron, 1997
  • BE (Honors): Birla Institute of Technology & Science, Pilani, India, 1992
Honors and Awards
  • Elected Fellow, American Association of Physicists in Medicine, 2016
  • Editor’s Choice in Basic Science, Journal of Neurointerventional Surgery, 2015
  • Farrington Daniels Award, American Association of Physicists in Medicine, 2008
  • Best Diagnostic Paper, Southeastern Chapter of the American Association of Physicists in Medicine, 2008
  • Cancer Research Award, Georgia Cancer Coalition, 2006
  • Dr. Karen Mudry Award, Institute of Biomedical Engineering Research, 1997

Select Publications

2025

Tseng, H. Wu, Z. Fu, and S. Vedantham, "Simultaneous reduction of radiation dose and scatter-to-primary ratio using a truncated detector and advanced algorithms for dedicated cone-beam breast CT.", Biomed Phys Eng Express, vol. 11, issue 2, 2025 Mar 03. PMCID: PMC12047646  PMID: 39983239
Mushtaq, R., A. Bhandari, S. Vedantham, R. Joseph Wruble, U. Udayasankar, and S. N. Rogers, "Investigating hyperostosis frontalis interna: a computed tomography analysis and predictive model for Hershkovitz classification.", Acta Radiol, pp. 2841851251313557, 2025 Feb 03.
Chen, J. Y., S. Vedantham, and F. J. Lexa, "3rd Comprehensive Survey of the Neuroradiology Work Environment in the United States with Reported Trends in Clinical Work, Nonclinical Work, Errors, Burnout and Retirement.", AJNR Am J Neuroradiol, 2025 Jul 03.
Kolstad, J., C. Zoppo, J. M. Johnston, P. D'Souza, A. Luisa Kühn, Z. Vardar, A. Peker, A. Hader, H. Celik, C. J. Lewis, et al., "Natural history progression of MRI brain volumetrics in type II late-infantile and juvenile GM1 gangliosidosis patients.", Mol Genet Metab, vol. 144, issue 3, pp. 109025, 2025 Jan 19.

2024

Di Maria, S., T. J. A. van Nijnatten, C. R. L. P. N. Jeukens, S. Vedantham, M. Dietzel, and P. Vaz, "Understanding the risk of ionizing radiation in breast imaging: Concepts and quantities, clinical importance, and future directions.", Eur J Radiol, vol. 181, pp. 111784, 2024 Dec. PMCID: PMC12148680  PMID: 39423780
Layman, R. R., S. Leng, K. L. Boedeker, L. M. Burk, H. Dang, X. Duan, M. C. Jacobsen, B. Li, K. Li, K. Little, et al., "AAPM Task Group Report 299: Quality control in multi-energy computed tomography.", Med Phys, 2024 Jul 29.
Fu, Z., H. Wu Tseng, and S. Vedantham, "An attenuation field network for dedicated cone beam breast CT with short scan and offset detector geometry.", Sci Rep, vol. 14, issue 1, pp. 319, 2024 Jan 03. PMCID: PMC10764954  PMID: 38172250
Larsen, T., H. Wu Tseng, R. Trinate, Z. Fu, J-T. Alan Chiang, A. Karellas, and S. Vedantham, "Maximizing microcalcification detectability in low-dose dedicated cone-beam breast CT: parallel cascades-based theoretical analysis.", J Med Imaging (Bellingham), vol. 11, issue 3, pp. 033501, 2024 May. PMCID: PMC11095120 
Nisbet, A. I., D. Ahmadian, S. Vedantham, and J-T. Alan Chiang, "An unusual artifact observed on screening mammography in a patient with an LVAD.", J Appl Clin Med Phys, vol. 25, issue 2, pp. e14255, 2024 Feb. PMCID: PMC10860483 

2023

Vijayaraghavan, G. R., C. Ge, A. Lee, J. G. Roubil, D. H. Kandil, K. H. Dinh, and S. Vedantham, "Savi-Scout Radar Localization: Transitioning From the Traditional Wire Localization to Wireless Technology for Surgical Guidance at Lumpectomies.", Semin Ultrasound CT MR, vol. 44, issue 1, pp. 12-17, 2023 Feb.
Tseng, H. Wu, A. Karellas, and S. Vedantham, "Dedicated cone-beam breast CT: Data acquisition strategies based on projection angle-dependent normalized glandular dose coefficients.", Med Phys, vol. 50, issue 3, pp. 1406-1417, 2023 Mar. PMCID: PMC10207937  PMID: 36427332
Shazeeb, M. Salman, V. Moholkar, R. M. King, S. Vedantham, Z. Vardar, A. Kraitem, C. Lindsay, V. Anagnostakou, J. Singh, F. Massari, et al., "Assessment of thrombectomy procedure difficulty by neurointerventionalists based on vessel geometry parameters from carotid artery 3D reconstructions.", J Clin Neurosci, vol. 113, pp. 121-125, 2023 Jul.
S, V., T. H. W, F. Z, and H-H. S. C, "Dedicated Cone-Beam Breast CT: Reproducibility of Volumetric Glandular Fraction with Advanced Image Reconstruction Methods", Tomography, vol. 9, issue 6, 11/2023.
Vedantham, S., M. Salman Shazeeb, A. Chiang, and G. R. Vijayaraghavan, "Artificial Intelligence in Breast X-Ray Imaging.", Semin Ultrasound CT MR, vol. 44, issue 1, pp. 2-7, 2023 Feb. PMCID: PMC9932302  PMID: 36792270
Vedantham, S., "Contrast-enhanced breast computed tomography: can lymph node metastasis be predicted from primary tumor?", Eur Radiol, 2023 Nov 06. PMCID: 3524966 
Vijayaraghavan, G. R., I. M. Guembou, and S. Vedantham, "The Current State of Timeliness in the Breast Cancer Diagnosis Journey: Abnormal Screening to Biopsy.", Semin Ultrasound CT MR, vol. 44, issue 1, pp. 56-61, 2023 Feb. PMCID: PMC12103741  PMID: 36792274
Vijayargahavan, G. R., J. Watkins, M. Tyminski, S. Venkataraman, N. Amornsiripanitch, A. Newburg, E. Ghosh, and S. Vedantham, "Audit of Prior Screening Mammograms of Screen-Detected Cancers: Implications for the Delay in Breast Cancer Detection.", Semin Ultrasound CT MR, vol. 44, issue 1, pp. 62-69, 2023 Feb. PMCID: PMC9932301  PMID: 36792275

2022

Vedantham, S., and A. Karellas, "Breast Cancer Screening: Opportunities and Challenges with Fully 3D Tomographic X-Ray Imaging.", Bridge (Wash D C), vol. 52, issue 1, pp. 33-42, 2022 Spring. PMCID: PMC9012464 
Roychowdhury, P., G. R. Vijayaraghavan, J. Roubil, I. M. Williams, E. Siddiqui, and S. Vedantham, "Value of BI-RADS 3 Audits.", Biomed J Sci Tech Res, vol. 41, issue 5, pp. 33086-33092, 2022 Feb. PMCID: PMC8983005  PMID: 35392255
Chen, J. Y., S. Vedantham, and F. J. Lexa, "Burnout and work-work imbalance in radiology- wicked problems on a global scale. A baseline pre-COVID-19 survey of US neuroradiologists compared to international radiologists and adjacent staff.", Eur J Radiol, vol. 155, pp. 110153, 2022 Oct.
Chen, J., S. Vedantham, and F. Lexa, Burnout and Work-Work Imbalance in Radiology- Wicked Problems on a Global Scale. A Baseline Pre-COVID-19 Survey of US Neuroradiologists Compared to International Radiologists and Adjacent Staff, 2022.
Di Maria, S., S. Vedantham, and P. Vaz, "Breast dosimetry in alternative X-ray-based imaging modalities used in current clinical practices.", Eur J Radiol, vol. 155, pp. 110509, 2022 Oct. PMCID: PMC9851082  PMID: 36087425
Tseng, H. Wu, A. Karellas, and S. Vedantham, "Cone-beam breast CT using an offset detector: effect of detector offset and image reconstruction algorithm.", Phys Med Biol, vol. 67, issue 8, 2022 Apr 07. PMID: 35316793
Karellas, A., A. RJ, C. MF, E. J, J. CE, S. M, S. P, and V. S, Continuous Professional Improvement (CPI) Physics in Imaging Special Edition Module: American College of Radiology (ACR) , 2022.

2021

Sawyer, D. M., R. Mushtaq, S. Vedantham, F. Shareef, S. M. Desoky, H. Arif-Tiwari, D. L. Gilbertson-Dahdal, and U. K. Udayasankar, "Performance of overnight on-call radiology residents in interpreting unenhanced abdominopelvic magnetic resonance imaging studies performed for pediatric right lower quadrant abdominal pain.", Pediatr Radiol, 2021 Mar 10.
Tseng, H., A. Karellas, and S. Vedantham, "Radiation dosimetry of a clinical prototype dedicated cone‐beam breast CT system with offset detector", Medical Physics, 01/2021.
Tseng, H. Wu, A. Karellas, and S. Vedantham, "Radiation dosimetry of a clinical prototype dedicated cone-beam breast CT system with offset detector.", Med Phys, vol. 48, issue 3, pp. 1079-1088, 2021 Mar. PMCID: PMC9007273  PMID: 33501686
Li, Z., Z. Fu, M. Keerthivasan, A. Bilgin, K. Johnson, J-P. Galons, S. Vedantham, D. R. Martin, and M. I. Altbach, "Rapid high-resolution volumetric T mapping using a highly accelerated stack-of-stars Look Locker technique.", Magn Reson Imaging, vol. 79, pp. 28-37, 2021 Mar 17. PMID: 33722634
Vijayaraghavan, G. R., M. Kona, A. Maheswaran, D. H. Kandil, M. K. Toke, and S. Vedantham, "Ultrasound Imaging Morphology is Associated with Biological Behavior in Invasive Ductal Carcinoma of the Breast.", J Clin Imaging Sci, vol. 11, pp. 48, 2021. PMCID: PMC8422408  PMID: 34513212

2020

Vedantham, S., H. Wu Tseng, S. Konate, L. Shi, and A. Karellas, "Dedicated cone-beam breast CT using laterally-shifted detector geometry: Quantitative analysis of feasibility for clinical translation", Journal of X-Ray Science and Technology,, 04/2020.
Sawyer, D., R. Mushtaq, S. Vedantham, and U. Udayasankar, Performance of overnight on-call radiology residents in interpreting unenhanced adbominopelvic MRI studies performed for pediatric right lower quadrant pain, 2020.
Tseng, H. Wu, S. Vedantham, and A. Karellas, "Cone-beam breast computed tomography using ultra-fast image reconstruction with constrained, total-variation minimization for suppression of artifacts", Physica Medica, vol. 73, 05/2020.
Tseng, H. Wu, A. Karellas, and S. Vedantham, "Sparse-view, short-scan, dedicated cone-beam breast computed tomography: image quality assessment.", Biomed Phys Eng Express, vol. 6, issue 6, 2020 Sep 28. PMCID: PMC8004539  PMID: 33377758
Liau, J., S. Vedantham, H. M. Babiker, T. McGlothin, and D. R. Martin, "Quantitative metric for assessment of pancreatic ductal adenocarcinoma treatment response in T1-weighted gadolinium-enhanced magnetic resonance imaging.", Ann Pancreat Cancer, vol. 3, 2020 Nov. PMCID: PMC7755136  PMID: 33367272
Fu, Z., H. Wu Tseng, S. Vedantham, A. Karellas, and A. Bilgin, "A residual dense network assisted sparse view reconstruction for breast computed tomography.", Sci Rep, vol. 10, issue 1, pp. 21111, 2020 Dec 03. PMCID: PMC7713379  PMID: 33273541
Tseng, H. Wu, A. Karellas, and S. Vedantham, "Sparse-view, short-scan, dedicated cone-beam breast computed tomography: image quality assessment", Biomedical Physics & Engineering Express , vol. 6, issue 6, 09, 2020.
Fu, Z., H. Wu Tseng, S. Vedantham, A. Karellas, and A. Bilgin, "A residual dense network assisted sparse view reconstruction for breast computed tomography", Scientific Reports, vol. 10; 21111, 12/2020.
Liau, J., S. Vedantham, H. M. Babiker, T. McGlothin, and D. R. Martin, "Quantitative metric for assessment of pancreatic ductal adenocarcinoma treatment response in T1-weighted gadolinium-enhanced magnetic resonance imaging", Annals of Pancreatic Cancer, vol. 3, 11/2020.
Tseng, H. W., A. Karellas, and S. Vedantham, "Sparse-view, short-scan, dedicated cone-beam breast computed tomography: Image quality assessment.", Biomedical Physics & Engineering Express, vol. 5, 09/ 2020.
Vedantham, S., H-W. Tseng, S. Konate, L. Shi, and A. Karellas, "Dedicated cone-beam breast CT using laterally-shifted detector geometry: Quantitative analysis of feasibility for clinical translation.", J Xray Sci Technol, vol. 28, issue 3, pp. 405-426, 2020. PMCID: PMC7347391  PMID: 32333575
Kotecha, H. M., H. S. Lo, S. Vedantham, H. Shin, and C. A. Cerniglia, "Abbreviated MRI of the foot in patients with suspected osteomyelitis.", Emerg Radiol, vol. 27, issue 1, pp. 9-16, 2020 Feb.

2019

Tseng, H. W., S. Vedantham, S. H. Cho, and A. Karellas, "Joint optimization of collimator and reconstruction parameters in x-ray fluorescence computed tomography using analytical point spread function and model observer.", IEEE Trans Biomed Eng, 2019 Dec 30. PMID: 31899411
Vijayaraghavan, G. R., A. Newburg, and S. Vedantham, "Positive Predictive Value of Tomosynthesis-guided Biopsies of Architectural Distortions Seen on Digital Breast Tomosynthesis and without an Ultrasound Correlate.", J Clin Imaging Sci, vol. 9, pp. 53, 2019. PMCID: PMC6884982  PMID: 31819830
Mushtaq, R., S. Desoky, F. Morello, D. Gilbertson-Dahdal, S. Vedantham, B. Kalb, D. Martin, and U. Udayasankar, First-Line Diagnostic Evaluation of Children with Suspected Acute Appendicitis using MRI, 2019.
Mushtaq, R., S. M. Desoky, F. Morello, D. Gilbertson-Dahdal, G. Gopalakrishnan, A. Leetch, S. Vedantham, B. Kalb, D. R. Martin, and U. K. Udayasankar, "First-Line Diagnostic Evaluation with MRI of Children Suspected of Having Acute Appendicitis.", Radiology, vol. 291, issue 1, pp. 170-177, 2019 04.
Deng, L., S. Yasar, M. Foiez Ahmed, S. Jayarathna, P. Feng, B. Wei, S. Vedantham, A. Karellas, and S. Hyun Cho, "Investigation of transmission computed tomography (CT) image quality and x-ray dose achievable from an experimental dual-mode benchtop x-ray fluorescence CT and transmission CT system.", J Xray Sci Technol, vol. 27, issue 3, pp. 431-442, 2019. PMCID: PMC7027361  PMID: 30909268
Z, L., B. A, J. K, G. J-P, V. S, and et. al Martin DR, "Rapid High-Resolution T1 Mapping Using a Highly Accelerated Radial Steady-state Free-precession Technique", J Magn Reson Imaging, issue 49 (1), pp. 239-252, 01/2019.

2018

O'Connell, A. M., A. Karellas, S. Vedantham, and D. T. Kawakyu-O'Connor, "Newer Technologies in Breast Cancer Imaging: Dedicated Cone-Beam Breast Computed Tomography.", Semin Ultrasound CT MR, vol. 39, issue 1, pp. 106-113, 2018 Feb. PMCID: PMC5957539  PMID: 29317032
Sujlana, P. S., M. Mahesh, S. Vedantham, S. C. Harvey, L. A. Mullen, and R. W. Woods, "Digital breast tomosynthesis: Image acquisition principles and artifacts.", Clin Imaging, 2018 Sep 13.
Vedantham, S., and A. Karellas, "Emerging Breast Imaging Technologies on the Horizon.", Semin Ultrasound CT MR, vol. 39, issue 1, pp. 114-121, 2018 Feb. PMCID: PMC5773258  PMID: 29317033
Arif-Tiwari, H., C. O. Twiss, F. C. Lin, J. T. Funk, S. Vedantham, D. R. Martin, and B. T. Kalb, "Improved Detection of Pelvic Organ Prolapse: Comparative Utility of Defecography Phase Sequence to Nondefecography Valsalva Maneuvers in Dynamic Pelvic Floor Magnetic Resonance Imaging.", Curr Probl Diagn Radiol, 2018 Aug 23.
Shi, L., S. Vedantham, A. Karellas, and L. Zhu, "The role of off-focus radiation in scatter correction for dedicated cone beam breast CT.", Med Phys, vol. 45, issue 1, pp. 191-201, 2018 Jan. PMCID: PMC5985236  PMID: 29159941
Vijayaraghavan, G. R., S. Vedantham, G. Santos-Nunez, and R. Hultman, "Unifocal Invasive Lobular Carcinoma: Tumor Size Concordance Between Preoperative Ultrasound Imaging and Postoperative Pathology.", Clin Breast Cancer, 2018 Jul 27. PMID: 30131246

2017

Shrestha, S., S. Vedantham, and A. Karellas, "Towards standardization of x-ray beam filters in digital mammography and digital breast tomosynthesis: Monte Carlo simulations and analytical modelling.", Phys Med Biol, vol. 62, issue 5, pp. 1969-1993, 2017 Mar 07. PMCID: PMC5384796  PMID: 28075335
Taschner, C. A., S. Vedantham, J. de Vries, A. Biondi, J. Boogaarts, N. Sakai, P. Lylyk, I. Szikora, S. Meckel, H. Urbach, et al., "Surpass Flow Diverter for Treatment of Posterior Circulation Aneurysms.", AJNR Am J Neuroradiol, vol. 38, issue 3, pp. 582-589, 2017 Mar.
Marosfoi, M., E. T. Langan, L. Strittmatter, K. van der Marel, S. Vedantham, J. Arends, I. R. Lylyk, S. Loganathan, G. M. Hendricks, I. Szikora, et al., "In situ tissue engineering: endothelial growth patterns as a function of flow diverter design.", J Neurointerv Surg, vol. 9, issue 10, pp. 994-998, 2017 Oct.
Shi, L., S. Vedantham, A. Karellas, and L. Zhu, "X-ray scatter correction for dedicated cone beam breast CT using a forward-projection model.", Med Phys, vol. 44, issue 6, pp. 2312-2320, 2017 Jun.
van der Marel, K., S. Vedantham, I. M. J. van der Bom, M. Howk, T. Narain, K. Ty, A. Karellas, M. J. Gounis, A. S. Puri, and A. K. Wakhloo, "Reduced Patient Radiation Exposure during Neurodiagnostic and Interventional X-Ray Angiography with a New Imaging Platform.", AJNR Am J Neuroradiol, vol. 38, issue 3, pp. 442-449, 2017 Mar. PMCID: PMC7959998 
Ulano, A. C., S. Vedantham, and D. Takhtani, "Revisiting the indirect signs of a temporal bone fracture: air, air, everywhere.", Emerg Radiol, 2017 Apr 03.
Vijayaraghavan, G. R., S. Vedantham, M. Kataoka, C. DeBenedectis, and R. M. Quinlan, "The Relevance of Ultrasound Imaging of Suspicious Axillary Lymph Nodes and Fine-needle Aspiration Biopsy in the Post-ACOSOG Z11 Era in Early Breast Cancer.", Acad Radiol, vol. 24, issue 3, pp. 308-315, 2017 Mar. PMCID: PMC5309157  PMID: 27916595
Marosfoi, M., F. Clarencon, E. T. Langan, R. M. King, O. W. Brooks, T. Tamura, J. M. Wainwright, M. J. Gounis, S. Vedantham, and A. S. Puri, "Acute thrombus formation on phosphorilcholine surface modified flow diverters.", J Neurointerv Surg, 2017 Jul 08.